Fig. 2

Stimulation amplitudes to activate fibers from individual-specific models of acute VNS in populations of rat, pig, and human nerves with 0.25 ms/phase biphasic rectangular waveform. A Dose–response curves for A fibers in rat nerves (n = 9). B Dose–response curves for A fibers in pig nerves (n = 12). C Dose–response curves for A fibers in human nerves (n = 9). Data for each nerve have a different color in panels (A-C). D Dose–response curves from panels (A-C) for A fibers with 0.25 ms/phase biphasic rectangular waveform. E Example dose–response curve for A fibers in a human model to show calculated threshold currents for each activation level (i.e., I₂₀, I₅₀, I₈₀, and I₁₀₀). F I₂₀, I₅₀, I₈₀, and I₁₀₀ threshold currents for A and B fibers in populations of humans, pigs, and rats. Each marker is a different individual