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Fig. 1 | Bioelectronic Medicine

Fig. 1

From: Scaling of vagus nerve stimulation parameters does not achieve equivalent nerve responses across species

Fig. 1

Histology-based computational models of vagus nerve stimulation (VNS) using individual-specific nerve morphology for humans, pigs, and rats. A Example histology and digitized nerve maps for human (Pelot et al., 2022a), pig (Pelot et al., 2022b), and rat (Pelot et al., 2022c) vagus nerves to show differences between species. Digitized nerve maps for all human and pig samples are available in (Musselman et al., 2023b), Fig. 1b and Supplemental Fig. 7f, respectively. We included an enlarged image of the rat nerve histology for clarity; the left-hand rat image is at the same scale as the human and pig histology. B Example finite element models of human, pig, and rat VNS using cuff electrodes that are used clinically (LivaNova helical cuff for pigs and humans) or used in preclinical studies (Micro-Leads Neuro for rats)

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Bioelectronic Medicine

ISSN: 2332-8886