Fig. 3
From: Using neural biomarkers to personalize dosing of vagus nerve stimulation

Recordings of evoked compound action potentials (eCAPs) A Neurograms at increasing currents (pulse width 500\(\,\upmu\)s, frequency 10 Hz, duration 1 s). Solid lines and confidence intervals respectively show the average and 5th/95th percentiles of the detrended response across the 10 pulses forming each stimulation train. For currents \(>={1.0}\) mA, dotted lines show the average response after substracting the average 0.5 mA response to isolate the B-fiber eCAP from the muscle artefact. The stimulation artefacts are not shown as these are detrended responses. Raw recordings with the stimulation artefact are shown in the Supplementary Materials. B Propagation of the neural signal between different stimulation sites and recording locations for A\(\beta\) and A\(\gamma\) eCAPs (current 0.25 mA, pulse width 130\(\,\upmu\)s, frequency 10 Hz, train 1 s). Cuffs A, B and C correspond to Group 1 cuff layout, as illustrated Fig. 2. Distances between the stimulation and recording site are shown in the legend. The propagation of the A\(\beta\) and A\(\gamma\) eCAPs are consistent with known conduction velocities. The location of the muscle artefact between 4-8 ms is independent of the distance of each recording cuff to the stimulation cuff. The polarity changes since the bipolar electrode arrangement is reversed between the two cuffs