Fig. 2

Null effect of uridine on short-term synaptic plasticity. a Representative traces showing paired pulse stimulation at inter-pulse intervals (IPI) of 50 ms and 100 ms from brain slices treated with high uridine (300 μM). Stimulation artifacts have been removed and are marked by arrowheads. b Graph showing the paired-pulse ratios (mean ± SEM) across a range of IPIs in brain slices treated with high uridine (300 μM). Ratios above 1.0 indicate paired-pulse facilitation (PPF), which is similar in the uridine and control groups; P1, slope of fEPSP in response to first pulse; P2, slope of fEPSP in response to second pulse. c Graphs showing the paired-pulse ratios (mean ± SEM) at a single IPI (50 ms) for uridine at three concentrations and control groups. All groups display comparable paired-pulse facilitation. Numbers within bars indicate number of brain slices per group